Heparin sodium CAS 9041-08-1

ʻO ka sodium Heparin kahi lāʻau anticoagulant, kahi mea mucopolysaccharide.ʻO ia ka paʻakai sodium o ka glucosamine sulfate i lawe ʻia mai ka mucosa ʻōpū o nā puaʻa, pipi a me nā hipa.waena.ʻO ka sodium Heparin ka hana o ka pale ʻana i ka platelet aggregation a me ka luku ʻana, kaohi ʻana i ka hoʻololi ʻana o ka fibrinogen i ka monomer fibrin, kaohi ʻana i ka hoʻokumu ʻana o ka thromboplastin a me ka pale ʻana i ka thromboplastin i hoʻokumu ʻia, e pale ana i ka hoʻololi ʻana o ka prothrombin i thrombin a me antithrombin.

Hiki i ka Heparin sodium ke hoʻopaneʻe a pale i ka coagulation koko ma ka vitro a me ka vivo.He paʻakikī loa kona ʻano hana a pili i nā loulou he nui i ke kaʻina coagulation.ʻO kāna mau hana: ①Kaohi i ka hoʻokumu ʻana a me ka hana o ka thromboplastin, a laila pale i ka prothrombin mai ka lilo ʻana i thrombin;②Ma nā kiʻekiʻe kiʻekiʻe, hiki iā ia ke kāohi i ka thrombin a me nā mea coagulation ʻē aʻe, e pale ana i ka fibrinogen mai ka lilo ʻana i fibrin Protein;③ hiki ke pale i ka hōʻuluʻulu a me ka luku ʻana i nā platelets.Eia kekahi, pili mau ka hopena anticoagulant o ka sodium heparin i ka radical sulfate i hoʻopiʻi ʻia i loko o kāna mole.Hiki i nā mea alkaline i ho'opi'i maika'i'ia e like me ka protamine a i 'ole toluidine blue ke ho'opau i kona ho'opi'i 'ino, no laila hiki iā ia ke pale i kona anticoagulant.coagulation.No ka mea hiki i ka heparin ke ho'āla a hoʻokuʻu i ka lipoprotein lipase i loko o ke kino, hydrolyze triglyceride a me ka lipoprotein haʻahaʻa haʻahaʻa i nā chylomicrons, no laila he hopena hypolipidemic pū kekahi.

Hiki ke hoʻohana ʻia ka sodium Heparin e mālama i ka maʻi thromboembolic acute, disseminated intravascular coagulation (DIC).I nā makahiki i hala iho nei, ua ʻike ʻia ka heparin i ka hopena o ka wehe ʻana i nā lipids koko.Intravenous injection a hohonu intramuscular injection (a i ʻole subcutaneous injection), 5,000 a 10,000 mau ʻāpana i kēlā me kēia manawa.ʻAʻole ʻawaʻawa ʻo Heparin sodium a ʻo ke kahe koko ʻokoʻa ka pilikia nui o ka overdose heparin.ʻAʻole maikaʻi ma ka waha, pono e lawelawe ʻia e ka injection.ʻOi aku ka hoʻonāukiuki ʻana o ka hoʻokele intramuscular a i ʻole ka subcutaneous, i kekahi manawa hiki ke loaʻa nā hopena maʻi, a hiki i ka overdose ke kumu i ka hopu ʻana i ka naʻau;ʻO ka poho lauoho a me ka maʻi maʻi i kekahi manawa.Eia kekahi, hiki ke hana i nā haʻihaʻi kuʻuna.Hiki i ka hoʻohana lōʻihi ke hoʻoulu i ka thrombosis i kekahi manawa, ʻo ia paha ka hopena o ka pau ʻana o ka anticoagulase-III.Hoʻopaʻa ʻia ʻo Heparin sodium i nā mea maʻi me ka maʻi koko, ka ate koʻikoʻi a me ka renal insufficiency, hypertension koʻikoʻi, hemophilia, intracranial hemorrhage, peptic ulcer, nā wahine hāpai a me ka postpartum, nā ʻōpū visceral, trauma a me ka ʻoki.